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Differential Retention of Pfam Domains Contributes to Long-term Evolutionary Trends

Protein domains that emerged more recently in evolution have a higher structural disorder and greater clustering of hydrophobic residues along the primary sequence. It is hard to explain how selection acting via descent with modification could act so slowly as not to saturate over the extraordinaril...

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Detalles Bibliográficos
Autores principales: James, Jennifer E, Nelson, Paul G, Masel, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089649/
https://www.ncbi.nlm.nih.gov/pubmed/36947137
http://dx.doi.org/10.1093/molbev/msad073