Multi-targeted therapy resistance via drug-induced secretome fucosylation

Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive. Here, we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted t...

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Detalles Bibliográficos
Autores principales: Aldonza, Mark Borris D, Cha, Junghwa, Yong, Insung, Ku, Jayoung, Sinitcyn, Pavel, Lee, Dabin, Cho, Ryeong-Eun, Delos Reyes, Roben D, Kim, Dongwook, Kim, Soyeon, Kang, Minjeong, Ku, Yongsuk, Park, Geonho, Sung, Hye-Jin, Ryu, Han Suk, Cho, Sukki, Kim, Tae Min, Kim, Pilnam, Cho, Je-Yoel, Kim, Yoosik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089660/
https://www.ncbi.nlm.nih.gov/pubmed/36961502
http://dx.doi.org/10.7554/eLife.75191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089660/
https://www.ncbi.nlm.nih.gov/pubmed/36961502
http://dx.doi.org/10.7554/eLife.75191

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