Experimental characterization of de novo proteins and their unevolved random-sequence counterparts

De novo gene emergence provides a route for new proteins to be formed from previously non-coding DNA. Proteins born in this way are considered random sequences and typically assumed to lack defined structure. While it remains unclear how likely a de novo protein is to assume a soluble and stable ter...

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Detalles Bibliográficos
Autores principales: Heames, Brennen, Buchel, Filip, Aubel, Margaux, Tretyachenko, Vyacheslav, Loginov, Dmitry, Novák, Petr, Lange, Andreas, Bornberg-Bauer, Erich, Hlouchová, Klára
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089919/
https://www.ncbi.nlm.nih.gov/pubmed/37024625
http://dx.doi.org/10.1038/s41559-023-02010-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089919/
https://www.ncbi.nlm.nih.gov/pubmed/37024625
http://dx.doi.org/10.1038/s41559-023-02010-2

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