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Experimental characterization of de novo proteins and their unevolved random-sequence counterparts
De novo gene emergence provides a route for new proteins to be formed from previously non-coding DNA. Proteins born in this way are considered random sequences and typically assumed to lack defined structure. While it remains unclear how likely a de novo protein is to assume a soluble and stable ter...
Autores principales: | Heames, Brennen, Buchel, Filip, Aubel, Margaux, Tretyachenko, Vyacheslav, Loginov, Dmitry, Novák, Petr, Lange, Andreas, Bornberg-Bauer, Erich, Hlouchová, Klára |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089919/ https://www.ncbi.nlm.nih.gov/pubmed/37024625 http://dx.doi.org/10.1038/s41559-023-02010-2 |
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