Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest in uncovering signalling vulnerabilities arising from this oncogenic el...

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Detalles Bibliográficos
Autores principales: Morrison, Kaitlin R., Wang, Tingting, Chan, Kuan Yoow, Trotter, Eleanor W., Gillespie, Ari, Michael, Michael Z., Oakhill, Jonathan S., Hagan, Iain M., Petersen, Janni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090877/
https://www.ncbi.nlm.nih.gov/pubmed/37042113
http://dx.doi.org/10.1098/rsob.230021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090877/
https://www.ncbi.nlm.nih.gov/pubmed/37042113
http://dx.doi.org/10.1098/rsob.230021

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