Enhancing Auxiliary‐Mediated Native Chemical Ligation at Challenging Junctions with Pyridine Scaffolds

To expand the scope of native chemical ligation (NCL) beyond reactions at cysteine, ligation auxiliaries are appended to the peptide N‐terminus. After the introduction of a pyridine‐containing auxiliary, which provided access to challenging junctions (proline or β‐branched amino acids), we herein pr...

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Detalles Bibliográficos
Autores principales: Trunschke, Sebastian, Piemontese, Emanuele, Fuchs, Olaf, Abboud, Skander, Seitz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091703/
https://www.ncbi.nlm.nih.gov/pubmed/36097325
http://dx.doi.org/10.1002/chem.202202065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091703/
https://www.ncbi.nlm.nih.gov/pubmed/36097325
http://dx.doi.org/10.1002/chem.202202065

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