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Enhancing Auxiliary‐Mediated Native Chemical Ligation at Challenging Junctions with Pyridine Scaffolds
To expand the scope of native chemical ligation (NCL) beyond reactions at cysteine, ligation auxiliaries are appended to the peptide N‐terminus. After the introduction of a pyridine‐containing auxiliary, which provided access to challenging junctions (proline or β‐branched amino acids), we herein pr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091703/ https://www.ncbi.nlm.nih.gov/pubmed/36097325 http://dx.doi.org/10.1002/chem.202202065 |