Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

Pseudo‐natural products (pseudo‐NPs) are de novo combinations of natural product (NP) fragments that define novel bioactive chemotypes. For their discovery, new design principles are being sought. Previously, pseudo‐NPs were synthesized by the combination of fragments originating from biosynthetical...

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Detalles Bibliográficos
Autores principales: Grigalunas, Michael, Patil, Sohan, Krzyzanowski, Adrian, Pahl, Axel, Flegel, Jana, Schölermann, Beate, Xie, Jianing, Sievers, Sonja, Ziegler, Slava, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091983/
https://www.ncbi.nlm.nih.gov/pubmed/36083197
http://dx.doi.org/10.1002/chem.202202164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091983/
https://www.ncbi.nlm.nih.gov/pubmed/36083197
http://dx.doi.org/10.1002/chem.202202164

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