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Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone
Pseudo‐natural products (pseudo‐NPs) are de novo combinations of natural product (NP) fragments that define novel bioactive chemotypes. For their discovery, new design principles are being sought. Previously, pseudo‐NPs were synthesized by the combination of fragments originating from biosynthetical...
Autores principales: | Grigalunas, Michael, Patil, Sohan, Krzyzanowski, Adrian, Pahl, Axel, Flegel, Jana, Schölermann, Beate, Xie, Jianing, Sievers, Sonja, Ziegler, Slava, Waldmann, Herbert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091983/ https://www.ncbi.nlm.nih.gov/pubmed/36083197 http://dx.doi.org/10.1002/chem.202202164 |
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