Cargando…

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex

The immune system detects virally or malignantly transformed cells via peptide‐loaded major histocompatibility complex class I (pMHC I) molecules on the cell surface. MHC I molecules are loaded with cargo peptides in the endoplasmic reticulum (ER) by the highly dynamic multiprotein peptide loading c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Winter, Christian, Domnick, Alexander, Cernova, Darja, Tampé, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092072/ https://www.ncbi.nlm.nih.gov/pubmed/36121731 http://dx.doi.org/10.1002/anie.202211826

Ejemplares similares

Molecular basis of MHC I quality control in the peptide loading complex
por: Domnick, Alexander, et al.
Publicado: (2022)

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
por: Brunnberg, Jamina, et al.
Publicado: (2021)

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex
por: Sethumadhavan, Sunesh, et al.
Publicado: (2022)

Dynamic interactome of the MHC I peptide loading complex in human dendritic cells
por: Barends, Martina, et al.
Publicado: (2023)

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells
por: Koller, Nicole, et al.
Publicado: (2022)

Molecular mechanism of peptide editing in the tapasin–MHC I complex
por: Fisette, Olivier, et al.
Publicado: (2016)

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch
por: Blees, Andreas, et al.
Publicado: (2015)

Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex
por: Hulpke, Sabine, et al.
Publicado: (2012)

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I
por: Sagert, Lina, et al.
Publicado: (2023)

Proofreading of Peptide—MHC Complexes through Dynamic Multivalent Interactions
por: Thomas, Christoph, et al.
Publicado: (2017)

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity
por: Müller, Ines Katharina, et al.
Publicado: (2022)

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor
por: Sagert, Lina, et al.
Publicado: (2020)

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes
por: Sun, Yi, et al.
Publicado: (2023)

Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation
por: Jiang, Jiansheng, et al.
Publicado: (2022)

Most viral peptides displayed by class I MHC on infected cells are immunogenic
por: Croft, Nathan P., et al.
Publicado: (2019)

Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection
por: Anjanappa, Raghavendra, et al.
Publicado: (2020)

TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap
por: McShan, Andrew C., et al.
Publicado: (2021)

Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities
por: Ritomská, Aneta, et al.
Publicado: (2023)

Semisynthetic Pneumococcal Glycoconjugate Nanovaccine
por: Prasanna, Maruthi, et al.
Publicado: (2023)

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation
por: Boff, Laurita, et al.
Publicado: (2020)

Scrutinizing MHC-I Binding Peptides and Their Limits of Variation
por: Koch, Christian P., et al.
Publicado: (2013)

Semisynthetic ‘designer’ p53 sheds light on a phosphorylation–acetylation relay
por: Margiola, Sofia, et al.
Publicado: (2021)

The V beta complementarity determining region 1 of a major histocompatibility complex (MHC) class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC II complex
Publicado: (1994)

TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
por: Szeto, Christopher, et al.
Publicado: (2020)

Presentation of numerous viral peptides to mouse major histocompatibility complex (MHC) class I-restricted T lymphocytes is mediated by the human MHC-encoded transporter or by a hybrid mouse- human transporter
Publicado: (1993)

Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents
por: Maafi, Negar, et al.
Publicado: (2021)

Structural Allele-Specific Patterns Adopted by Epitopes in the MHC-I Cleft and Reconstruction of MHC:peptide Complexes to Cross-Reactivity Assessment
por: Antunes, Dinler A., et al.
Publicado: (2010)

Semisynthetic roxburghin tetramethyl ether
por: Saez, Alex, et al.
Publicado: (2008)

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility
por: Ayres, Cory M., et al.
Publicado: (2019)

The MHC class I peptide repertoire is molded by the transcriptome
por: Fortier, Marie-Hélène, et al.
Publicado: (2008)

Specific MHC-I Peptides Are Induced Using PROTACs
por: Jensen, Stephanie M., et al.
Publicado: (2018)

Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules
por: Grimholt, Unni
Publicado: (2018)

Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities
por: Pedersen, Lasse Eggers, et al.
Publicado: (2011)

Reconstitution of class I MHC molecules expressed in E. coli and complexed with single antigenic peptides.
por: Kim, J., et al.
Publicado: (1997)

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach
por: Oueis, Emilia, et al.
Publicado: (2015)

Synthesis and characterization of semisynthetic analogs of the antifungal occidiofungin
por: Geng, Mengxin, et al.
Publicado: (2022)

Probing coenzyme A homeostasis with semisynthetic biosensors
por: Xue, Lin, et al.
Publicado: (2022)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

Opening opportunities for K(d) determination and screening of MHC peptide complexes
por: Kopicki, Janine-Denise, et al.
Publicado: (2022)

A Peptide Filtering Relation Quantifies MHC Class I Peptide Optimization
por: Dalchau, Neil, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6ggq40k0gff3dsq6991d4d32e3