The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay

To study the binding mode of the adipokine chemerin as well as the short peptide agonist chemerin‐9 (C9) to its two receptors chemokine‐like receptor 1 (CMKLR1) and G protein‐coupled receptor 1 (GPR1), we generated 5‐carboxytetramethylrhodamine (TAMRA) modified variants of both ligands. In addition,...

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Detalles Bibliográficos
Autores principales: Czerniak, Anne Sophie, Kretschmer, Kevin, Weiß, Tina, Beck‐Sickinger, Annette G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092101/
https://www.ncbi.nlm.nih.gov/pubmed/36178206
http://dx.doi.org/10.1002/cmdc.202200413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092101/
https://www.ncbi.nlm.nih.gov/pubmed/36178206
http://dx.doi.org/10.1002/cmdc.202200413

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