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Novel NRF2‐activated cancer treatments utilizing synthetic lethality
The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway occur commonly in human cancer, where they contribute to the formation of aggressive tumours that are associated with a poor prognosis for pat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092255/ https://www.ncbi.nlm.nih.gov/pubmed/36200139 http://dx.doi.org/10.1002/iub.2680 |