Importance of Co‐operative Hydrogen Bonding in the Apramycin‐Ribosomal Decoding A‐Site Interaction

An intramolecular hydrogen bond between the protonated equatorial 7’‐methylamino group of apramycin and the vicinal axial 6’‐hydroxy group acidifies the 6’‐hydroxy group leading to a strong hydrogen bond to A1408 in the ribosomal drug binding pocket in the decoding A site of the small ribosomal subu...

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Detalles Bibliográficos
Autores principales: Pirrone, Michael G., Ande, Chennaiah, Haldimann, Klara, Hobbie, Sven N., Vasella, Andrea, Böttger, Erik C., Crich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092258/
https://www.ncbi.nlm.nih.gov/pubmed/36198651
http://dx.doi.org/10.1002/cmdc.202200486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092258/
https://www.ncbi.nlm.nih.gov/pubmed/36198651
http://dx.doi.org/10.1002/cmdc.202200486

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