Multigenerational downregulation of insulin/IGF‐1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing

Adulthood‐only downregulation of insulin/IGF‐1 signaling (IIS), an evolutionarily conserved pathway regulating resource allocation between somatic maintenance and reproduction, increases life span without fecundity cost in the nematode, Caenorhabditis elegans. However, long‐term multigenerational ef...

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Detalles Bibliográficos
Autores principales: Duxbury, Elizabeth M. L., Carlsson, Hanne, Sales, Kris, Sultanova, Zahida, Immler, Simone, Chapman, Tracey, Maklakov, Alexei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092551/
https://www.ncbi.nlm.nih.gov/pubmed/36199198
http://dx.doi.org/10.1111/evo.14640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092551/
https://www.ncbi.nlm.nih.gov/pubmed/36199198
http://dx.doi.org/10.1111/evo.14640

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