Cargando…

Multigenerational downregulation of insulin/IGF‐1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing

Adulthood‐only downregulation of insulin/IGF‐1 signaling (IIS), an evolutionarily conserved pathway regulating resource allocation between somatic maintenance and reproduction, increases life span without fecundity cost in the nematode, Caenorhabditis elegans. However, long‐term multigenerational ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duxbury, Elizabeth M. L., Carlsson, Hanne, Sales, Kris, Sultanova, Zahida, Immler, Simone, Chapman, Tracey, Maklakov, Alexei A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092551/ https://www.ncbi.nlm.nih.gov/pubmed/36199198 http://dx.doi.org/10.1111/evo.14640

Ejemplares similares

Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans
por: Ivimey-Cook, Edward R., et al.
Publicado: (2021)

Fitness benefits of dietary restriction
por: Sultanova, Zahida, et al.
Publicado: (2021)

Cost-free lifespan extension via optimization of gene expression in adulthood aligns with the developmental theory of ageing
por: Lind, Martin I., et al.
Publicado: (2021)

Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
por: Lind, Martin I., et al.
Publicado: (2019)

Ageing as “early‐life inertia”: Disentangling life‐history trade‐offs along a lifetime of an individual
por: Carlsson, Hanne, et al.
Publicado: (2021)

Multigenerational Effects of Heavy Metals on Feeding, Growth, Initial Reproduction and Antioxidants in Caenorhabditis elegans
por: Yu, ZhenYang, et al.
Publicado: (2016)

Germline mutation rate is elevated in young and old parents in Caenorhabditis remanei
por: Chen, Hwei-yen, et al.
Publicado: (2023)

Global DNA Adenine Methylation in Caenorhabditis elegans after Multigenerational Exposure to Silver Nanoparticles and Silver Nitrate
por: Wamucho, Anye, et al.
Publicado: (2023)

Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans
por: Baugh, L Ryan, et al.
Publicado: (2020)

Evolution of ageing as a tangle of trade-offs: energy versus function
por: Maklakov, Alexei A., et al.
Publicado: (2019)

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegans
por: Lee, Hanseul, et al.
Publicado: (2022)

DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans
por: McHugh, Daniel R., et al.
Publicado: (2020)

Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway
por: Meng, Fanhui, et al.
Publicado: (2018)

The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans
por: Moll, Lorna, et al.
Publicado: (2018)

Disentangling the multigenerational transmissions of socioeconomic disadvantages and mental health problems by gender and across lineages: Findings from the Stockholm Birth Cohort Multigenerational Study
por: Li, Baojing, et al.
Publicado: (2023)

Disentangling the multigenerational transmissions of socioeconomic disadvantages and mental health problems by gender and across lineages: Findings from the Stockholm Birth Cohort Multigenerational Study
por: Li, B., et al.
Publicado: (2023)

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
por: Kimmerling, Robert J., et al.
Publicado: (2016)

mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage
por: Parker, Dylan M., et al.
Publicado: (2020)

Beneficial cumulative effects of old parental age on offspring fitness
por: Travers, Laura M., et al.
Publicado: (2021)

High-resolution imaging and analysis of the intestinal bacterial load of Caenorhabditis elegans during early adulthood
por: Rezaeianaran, Farzad, et al.
Publicado: (2023)

Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in Caenorhabditis elegans
por: Ackerman, Daniel, et al.
Publicado: (2012)

Caenorhabditis Elegans
Publicado: (2000)

Selection for longer lived sperm within ejaculate reduces reproductive ageing in offspring
por: Alavioon, Ghazal, et al.
Publicado: (2019)

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
por: Ashe, Alyson, et al.
Publicado: (2012)

Downregulation of transposable elements extends lifespan in Caenorhabditis elegans
por: Sturm, Ádám, et al.
Publicado: (2023)

Data in support of genome-wide identification of lineage-specific genes within Caenorhabditis elegans
por: Zhou, Kun, et al.
Publicado: (2015)

Antinematode Activity of Violacein and the Role of the Insulin/IGF-1 Pathway in Controlling Violacein Sensitivity in Caenorhabditis elegans
por: Ballestriero, Francesco, et al.
Publicado: (2014)

FGT‐1‐mediated glucose uptake is defective in insulin/IGF‐like signaling mutants in Caenorhabditis elegans
por: Kitaoka, Shun, et al.
Publicado: (2016)

Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans
por: Bai, Shuju, et al.
Publicado: (2022)

Caenorhabditis elegans glia modulate neuronal activity and behavior
por: Stout Jr., Randy F., et al.
Publicado: (2014)

The Multigenerational Sales Team
por: Shiver, Warren
Publicado: (2017)

The Nucleolus of Caenorhabditis elegans
por: Lee, Li-Wei, et al.
Publicado: (2012)

Immunometabolism in Caenorhabditis elegans
por: Anderson, Sarah M., et al.
Publicado: (2020)

Immunosenescence in Caenorhabditis elegans
por: Kim, Sieun S., et al.
Publicado: (2022)

Oogenesis in Caenorhabditis elegans
por: Davis, Gregory M., et al.
Publicado: (2023)

Single‐cell dynamics of chromatin activity during cell lineage differentiation in Caenorhabditis elegans embryos
por: Zhao, Zhiguang, et al.
Publicado: (2021)

Sex ratio at mating does not modulate age fitness effects in Drosophila melanogaster
por: Sultanova, Zahida, et al.
Publicado: (2019)

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans
por: Xiong, Li-Gui, et al.
Publicado: (2017)

Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration
por: Morton, Katherine S., et al.
Publicado: (2023)

Supplemental Cellular Protection by a Carotenoid Extends Lifespan via Ins/IGF-1 Signaling in Caenorhabditis elegans
por: Yazaki, Koumei, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4i9s8uqkue5hio2b0fo48s8uh3