Islet‐specific CD8 (+) T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry

Type 1 diabetes (T1D) is caused by aberrant activation of autoreactive T cells specific for the islet beta cells. How islet‐specific T cells evade tolerance to become effector T cells is unknown, but it is believed that an altered gut microbiota plays a role. Possible mechanisms include bystander ac...

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Detalles Bibliográficos
Autores principales: Okada, Mirei, Zhang, Vivian, Loaiza Naranjo, Jeniffer D, Tillett, Bree J, Wong, F Susan, Steptoe, Raymond J, Bergot, Anne‐Sophie, Hamilton‐Williams, Emma E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092732/
https://www.ncbi.nlm.nih.gov/pubmed/36214093
http://dx.doi.org/10.1111/imcb.12593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092732/
https://www.ncbi.nlm.nih.gov/pubmed/36214093
http://dx.doi.org/10.1111/imcb.12593

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