Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering

The cytochrome P450 (CYP) family of heme monooxygenases catalyse the selective oxidation of C−H bonds under ambient conditions. The CYP199A4 enzyme from Rhodopseudomonas palustris catalyses aliphatic oxidation of 4‐cyclohexylbenzoic acid but not the aromatic oxidation of 4‐phenylbenzoic acid, due to...

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Detalles Bibliográficos
Autores principales: Coleman, Tom, Lee, Joel Z. H., Kirk, Alicia M., Doherty, Daniel Z., Podgorski, Matthew N., Pinidiya, Dilshi K., Bruning, John B., De Voss, James J., Krenske, Elizabeth H., Bell, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092897/
https://www.ncbi.nlm.nih.gov/pubmed/36043399
http://dx.doi.org/10.1002/chem.202201895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092897/
https://www.ncbi.nlm.nih.gov/pubmed/36043399
http://dx.doi.org/10.1002/chem.202201895

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