Autophagy Inhibitor Chloroquine Downmodulates Hepatic Stellate Cell Activation and Liver Damage in Bile-Duct-Ligated Mice

Hepatic stellate cell (HSC) activation via the autophagy pathway is a critical factor in liver fibrogenesis. This study tests the hypothesis that chloroquine (CQ) treatment can prevent autophagy and HSC activation in vitro and in vivo in bile-duct-ligated (BDL) mice. Sham-operated and BDL mice were...

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Detalles Bibliográficos
Autores principales: Le, Trinh Van, Phan-Thi, Hong-Thuy, Huynh-Thi, My-Xuan, Dang, Thanh Minh, Holterman, Ai Xuan Le, Grassi, Gabriele, Nguyen-Luu, Thao-Uyen, Truong, Nhung Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092998/
https://www.ncbi.nlm.nih.gov/pubmed/37048098
http://dx.doi.org/10.3390/cells12071025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092998/
https://www.ncbi.nlm.nih.gov/pubmed/37048098
http://dx.doi.org/10.3390/cells12071025

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