CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma

SIMPLE SUMMARY: Human papilloma virus–negative (HPV(−)) oral cavity squamous cell carcinoma (OCSCC) is the leading cause of mortality amongst head and neck cancers. Radiation resistance remains a prime cause of treatment failure in OCSCC. Overall, failure to cure locally advanced OCSCC remains a for...

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Detalles Bibliográficos
Autores principales: Shrivastava, Nitisha, Chavez, Claudia Gutierrez, Li, Daniel, Mehta, Vikas, Thomas, Carlos, Fulcher, Cory D., Kawachi, Nicole, Bottalico, Danielle M., Prystowsky, Michael B., Basu, Indranil, Guha, Chandan, Ow, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093103/
https://www.ncbi.nlm.nih.gov/pubmed/37046664
http://dx.doi.org/10.3390/cancers15072005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093103/
https://www.ncbi.nlm.nih.gov/pubmed/37046664
http://dx.doi.org/10.3390/cancers15072005

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