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Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy

We have shown in vivo and in vitro previously that psychosine causes dysfunction of autophagy and the ubiquitin-proteasome system underlying the pathogenesis of globoid cell leukodystrophy (GLD), a devastating lysosomal storage disease complicated by global demyelination. Here, we investigated the t...

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Detalles Bibliográficos
Autores principales: Lin, Dar-Shong, Huang, Yu-Wen, Lee, Tsung-Han, Chang, Lung, Huang, Zon-Darr, Wu, Tsu-Yen, Wang, Tuan-Jen, Ho, Che-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093124/
https://www.ncbi.nlm.nih.gov/pubmed/37048066
http://dx.doi.org/10.3390/cells12070993