Prognostic Relevance and In Vitro Targeting of Concomitant PTEN and p16 Deficiency in Chordomas

SIMPLE SUMMARY: Chordomas are rare malignant bone tumors that predominantly occur along the spine. The most frequent alterations include the loss of PTEN and p16 proteins. While both oncoproteins have been investigated as independent prognostic factors, in our chordoma cohort of 43 patients we were...

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Detalles Bibliográficos
Autores principales: Seeling, Carolin, Mosca, Elena, Mantel, Eva, Möller, Peter, Barth, Thomas F. E., Mellert, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093147/
https://www.ncbi.nlm.nih.gov/pubmed/37046638
http://dx.doi.org/10.3390/cancers15071977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093147/
https://www.ncbi.nlm.nih.gov/pubmed/37046638
http://dx.doi.org/10.3390/cancers15071977

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