BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis

SIMPLE SUMMARY: To explore new drugs for malignant neuroblastoma, we used bioinformatics to analyze the prognostic genes, and successfully found the small molecular drug BI-D1870 based on the professional gene–drug analysis website ‘Connectivity Map’. In vivo and in vitro experiments confirmed that...

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Detalles Bibliográficos
Autores principales: Jin, Liming, Mi, Tao, Wu, Xin, Wang, Zhang, Zhang, Zhaoxia, Liu, Jiayan, Wang, Zhaoying, Wang, Jinkui, Li, Mujie, Ren, Chunnian, Guo, Peng, He, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093276/
https://www.ncbi.nlm.nih.gov/pubmed/37046682
http://dx.doi.org/10.3390/cancers15072023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093276/
https://www.ncbi.nlm.nih.gov/pubmed/37046682
http://dx.doi.org/10.3390/cancers15072023

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