α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization

Synucleinopathies form a group of neurodegenerative diseases defined by the misfolding and aggregation of α-synuclein (α-syn). Abnormal accumulation and spreading of α-syn aggregates lead to synapse dysfunction and neuronal cell death. Yet, little is known about the synaptic mechanisms underlying th...

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Detalles Bibliográficos
Autores principales: Feller, Benjamin, Fallon, Aurélie, Luo, Wen, Nguyen, Phuong Trang, Shlaifer, Irina, Lee, Alfred Kihoon, Chofflet, Nicolas, Yi, Nayoung, Khaled, Husam, Karkout, Samer, Bourgault, Steve, Durcan, Thomas M., Takahashi, Hideto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093570/
https://www.ncbi.nlm.nih.gov/pubmed/37048156
http://dx.doi.org/10.3390/cells12071083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093570/
https://www.ncbi.nlm.nih.gov/pubmed/37048156
http://dx.doi.org/10.3390/cells12071083

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