STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system. AxD-associated mutations cause GFAP aggregation and astrogliosis, and GFAP is elevated with the astrocyte stress resp...

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Detalles Bibliográficos
Autores principales: Hagemann, Tracy L., Coyne, Sierra, Levin, Alder, Wang, Liqun, Feany, Mel B., Messing, Albee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093589/
https://www.ncbi.nlm.nih.gov/pubmed/37048051
http://dx.doi.org/10.3390/cells12070978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093589/
https://www.ncbi.nlm.nih.gov/pubmed/37048051
http://dx.doi.org/10.3390/cells12070978

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