ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines

Constitutive activation of the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway is crucial for tumor growth and progression. As such, this pathway has been an enticing target for drug discovery. Although HS-173 is a potent PI3K inhibitor that halts cancer cell proliferation via G2/M cell cycle...

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Detalles Bibliográficos
Autores principales: Wu, Chung-Pu, Hung, Cheng-Yu, Hsieh, Ya-Ju, Murakami, Megumi, Huang, Yang-Hui, Su, Tsung-Yao, Hung, Tai-Ho, Yu, Jau-Song, Wu, Yu-Shan, Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093605/
https://www.ncbi.nlm.nih.gov/pubmed/37048130
http://dx.doi.org/10.3390/cells12071056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093605/
https://www.ncbi.nlm.nih.gov/pubmed/37048130
http://dx.doi.org/10.3390/cells12071056

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