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The Molecular Mechanisms and Therapeutic Prospects of Alternative Lengthening of Telomeres (ALT)

SIMPLE SUMMARY: This review summarizes the current understanding of the telomere maintenance mechanism known as the Alternative Lengthening of Telomeres (ALT). The role, recognizable indicators, and proposed mechanism of the ALT pathway in sustaining cancer cells are reviewed. Potential molecular ta...

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Detalles Bibliográficos
Autores principales: Sohn, Eric J., Goralsky, Julia A., Shay, Jerry W., Min, Jaewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093677/
https://www.ncbi.nlm.nih.gov/pubmed/37046606
http://dx.doi.org/10.3390/cancers15071945