Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time

Osteosarcoma is an aggressive malignancy characterized by high genomic complexity. Identification of few recurrent mutations in protein coding genes suggests that somatic copy-number aberrations (SCNA) are the genetic drivers of disease. Models around genomic instability conflict—it is unclear wheth...

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Detalles Bibliográficos
Autores principales: Rajan, Sanjana, Zaccaria, Simone, Cannon, Matthew V., Cam, Maren, Gross, Amy C., Raphael, Benjamin J., Roberts, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093779/
https://www.ncbi.nlm.nih.gov/pubmed/37066022
http://dx.doi.org/10.1158/2767-9764.CRC-22-0348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093779/
https://www.ncbi.nlm.nih.gov/pubmed/37066022
http://dx.doi.org/10.1158/2767-9764.CRC-22-0348

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