Synthesis and Structure–Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors

Salvinal is a natural lignan isolated from the roots of Salvia mitorrhiza Bunge (Danshen). Previous studies have demonstrated its anti-proliferative activity in both drug-sensitive and -resistant cancer cell lines, with IC(50) values ranging from 4–17 µM. In this study, a series of salvinal derivati...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Chi-I, Hsieh, Cheng-Chih, Wein, Yung-Shung, Kuo, Ching-Chuan, Chang, Chi-Yen, Lung, Jrhau, Cherng, Jong-Yuh, Chu, Po-Chen, Chang, Jang-Yang, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093915/
https://www.ncbi.nlm.nih.gov/pubmed/37047358
http://dx.doi.org/10.3390/ijms24076386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093915/
https://www.ncbi.nlm.nih.gov/pubmed/37047358
http://dx.doi.org/10.3390/ijms24076386

Ejemplares similares