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Synthesis and Structure–Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors

Salvinal is a natural lignan isolated from the roots of Salvia mitorrhiza Bunge (Danshen). Previous studies have demonstrated its anti-proliferative activity in both drug-sensitive and -resistant cancer cell lines, with IC(50) values ranging from 4–17 µM. In this study, a series of salvinal derivati...

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Detalles Bibliográficos
Autores principales:	Chang, Chi-I, Hsieh, Cheng-Chih, Wein, Yung-Shung, Kuo, Ching-Chuan, Chang, Chi-Yen, Lung, Jrhau, Cherng, Jong-Yuh, Chu, Po-Chen, Chang, Jang-Yang, Kuo, Yueh-Hsiung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093915/ https://www.ncbi.nlm.nih.gov/pubmed/37047358 http://dx.doi.org/10.3390/ijms24076386

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