ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels

ADAM10 is the main α-secretase acting in the non-amyloidogenic processing of APP. We hypothesized that certain rare ADAM10 variants could increase the risk for AD by conferring the age-related downregulation of α-secretase. The ADAM10 gene was sequenced in 103 AD cases (82% familial) and 96 cognitiv...

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Detalles Bibliográficos
Autores principales: Agüero-Rabes, Pablo, Pérez-Pérez, Julián, Cremades-Jimeno, Lucía, García-Ayllón, María-Salud, Gea-González, Adriana, Sainz, María José, Mahillo-Fernández, Ignacio, Téllez, Raquel, Cárdaba, Blanca, Sáez-Valero, Javier, Gómez-Tortosa, Estrella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093927/
https://www.ncbi.nlm.nih.gov/pubmed/37047093
http://dx.doi.org/10.3390/ijms24076113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093927/
https://www.ncbi.nlm.nih.gov/pubmed/37047093
http://dx.doi.org/10.3390/ijms24076113

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