Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone, PLB), a naturally occurring naphthoquinone mainly isolated from the plant Plumbago zeylanica L., has been proven to possess anticancer activities towards multiple types of cancer. Although there has been an increasing amount of research regarding its...

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Detalles Bibliográficos
Autores principales: Liu, Huan, Zhang, Wenchao, Jin, Lijie, Liu, Shasha, Liang, Liying, Wei, Yanfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094147/
https://www.ncbi.nlm.nih.gov/pubmed/37047251
http://dx.doi.org/10.3390/ijms24076279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094147/
https://www.ncbi.nlm.nih.gov/pubmed/37047251
http://dx.doi.org/10.3390/ijms24076279

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