HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction

The downregulation of Pleckstrin Homology-Like Domain family A member 1 (PHLDA1) expression mediates resistance to targeted therapies in receptor tyrosine kinase-driven cancers. The restoration and maintenance of PHLDA1 levels in cancer cells thus constitutes a potential strategy to circumvent resis...

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Detalles Bibliográficos
Autores principales: Clayton, Natasha S., Carter, Edward P., Fearon, Abbie E., Heward, James A., Rodríguez Fernández, Lucía, Boughetane, Lina, Wilkes, Edmund H., Cutillas, Pedro R., Grose, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094256/
https://www.ncbi.nlm.nih.gov/pubmed/37047202
http://dx.doi.org/10.3390/ijms24076228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094256/
https://www.ncbi.nlm.nih.gov/pubmed/37047202
http://dx.doi.org/10.3390/ijms24076228

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