1,3,8-Triazaspiro[4.5]decane Derivatives Inhibit Permeability Transition Pores through a F(O)-ATP Synthase c Subunit Glu(119)-Independent Mechanism That Prevents Oligomycin A-Related Side Effects

Permeability transition pore (PTP) molecular composition and activity modulation have been a matter of research for several years, especially due to their importance in ischemia reperfusion injury (IRI). Notably, c subunit of ATP synthase (Csub) has been identified as one of the PTP-forming proteins...

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Detalles Bibliográficos
Autores principales: Pedriali, Gaia, Ramaccini, Daniela, Bouhamida, Esmaa, Branchini, Alessio, Turrin, Giulia, Tonet, Elisabetta, Scala, Antonella, Patergnani, Simone, Pinotti, Mirko, Trapella, Claudio, Giorgi, Carlotta, Tremoli, Elena, Campo, Gianluca, Morciano, Giampaolo, Pinton, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094280/
https://www.ncbi.nlm.nih.gov/pubmed/37047160
http://dx.doi.org/10.3390/ijms24076191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094280/
https://www.ncbi.nlm.nih.gov/pubmed/37047160
http://dx.doi.org/10.3390/ijms24076191

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