Lipid-linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency

We designed and synthesized a series of 2′-deoxyribonucleoside triphosphates (dNTPs) bearing various lipid moieties. Fatty acid- and cholesterol-modified dNTPs proved to be substrates for KOD XL DNA polymerase in primer extension reactions. They were also mutually compatible for simultaneous multipl...

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Detalles Bibliográficos
Autores principales: Kodr, David, Kužmová, Erika, Pohl, Radek, Kraus, Tomáš, Hocek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094435/
https://www.ncbi.nlm.nih.gov/pubmed/37063801
http://dx.doi.org/10.1039/d2sc06718h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094435/
https://www.ncbi.nlm.nih.gov/pubmed/37063801
http://dx.doi.org/10.1039/d2sc06718h

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