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Effect of Single-Residue Mutations on CTCF Binding to DNA: Insights from Molecular Dynamics Simulations
In humans and other eukaryotes, DNA is condensed into chromatin fibers that are further wound into chromosomes. This organization allows regulatory elements in the genome, often distant from each other in the linear DNA, to interact and facilitate gene expression through regions known as topological...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094706/ https://www.ncbi.nlm.nih.gov/pubmed/37047368 http://dx.doi.org/10.3390/ijms24076395 |