How Single Amino Acid Substitutions Can Disrupt a Protein Hetero-Dimer Interface: Computational and Experimental Studies of the LigAB Dioxygenase from Sphingobium sp. Strain SYK-6

Protocatechuate 4,5-dioxygenase (LigAB) is a heterodimeric enzyme that catalyzes the dioxygenation of multiple lignin derived aromatic compounds. The active site of LigAB is at the heterodimeric interface, with specificity conferred by the alpha subunit and catalytic residues contributed by the beta...

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Detalles Bibliográficos
Autores principales: Rafalowski, Angelika, Hassan, Bakar A., Lou, Kate, Nguyen, Minh Chau, Taylor, Erika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094722/
https://www.ncbi.nlm.nih.gov/pubmed/37047291
http://dx.doi.org/10.3390/ijms24076319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094722/
https://www.ncbi.nlm.nih.gov/pubmed/37047291
http://dx.doi.org/10.3390/ijms24076319

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