Coarse-Grained Molecular Simulations and Ensemble-Based Mutational Profiling of Protein Stability in the Different Functional Forms of the SARS-CoV-2 Spike Trimers: Balancing Stability and Adaptability in BA.1, BA.2 and BA.2.75 Variants

Evolutionary and functional studies have suggested that the emergence of Omicron variants can be determined by multiple fitness tradeoffs including immune escape, binding affinity, conformational plasticity, protein stability, and allosteric modulation. In this study, we embarked on a systematic com...

Descripción completa

Detalles Bibliográficos
Autores principales: Verkhivker, Gennady, Alshahrani, Mohammed, Gupta, Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094791/
https://www.ncbi.nlm.nih.gov/pubmed/37047615
http://dx.doi.org/10.3390/ijms24076642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094791/
https://www.ncbi.nlm.nih.gov/pubmed/37047615
http://dx.doi.org/10.3390/ijms24076642

Ejemplares similares