Azacitidine Is Synergistically Lethal with XPO1 Inhibitor Selinexor in Acute Myeloid Leukemia by Targeting XPO1/eIF4E/c-MYC Signaling

Acute myeloid leukemia (AML) is a high-mortality malignancy with poor outcomes. Azacitidine induces cell death and demonstrates treatment effectiveness against AML. Selinexor (KPT-330) exhibited significant benefits in combination with typical induction treatment for AML patients. Here, we explore t...

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Detalles Bibliográficos
Autores principales: Long, Huideng, Hou, Yue, Li, Jun, Song, Chunhua, Ge, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094826/
https://www.ncbi.nlm.nih.gov/pubmed/37047788
http://dx.doi.org/10.3390/ijms24076816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094826/
https://www.ncbi.nlm.nih.gov/pubmed/37047788
http://dx.doi.org/10.3390/ijms24076816

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