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Up-Regulation of microRNA-424 Causes an Imbalance in AKT Phosphorylation and Impairs Enteric Neural Crest Cell Migration in Hirschsprung Disease

Insights into the role of microRNAs (miRNAs) in disease pathogenesis have made them attractive therapeutic targets, and numerous miRNAs have been functionally linked to Hirschsprung disease (HSCR), a life-threatening genetic disorder due to defective migration, proliferation, and colonization of ent...

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Detalles Bibliográficos
Autores principales: Xu, Ze, Yan, Yingnan, Gu, Beilin, Cai, Wei, Wang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094892/
https://www.ncbi.nlm.nih.gov/pubmed/37047673
http://dx.doi.org/10.3390/ijms24076700