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A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity

Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore, relaxin’s receptor, relaxin family peptide receptor 1 (RXFP1), is a potential target for the treatment of fibrosis and related disorders, including h...

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Detalles Bibliográficos
Autores principales: Praveen, Praveen, Wang, Chao, Handley, Thomas N. G., Wu, Hongkang, Samuel, Chrishan S., Bathgate, Ross A. D., Hossain, Mohammed Akhter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094921/
https://www.ncbi.nlm.nih.gov/pubmed/37047588
http://dx.doi.org/10.3390/ijms24076616