Cargando…

A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity

Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore, relaxin’s receptor, relaxin family peptide receptor 1 (RXFP1), is a potential target for the treatment of fibrosis and related disorders, including h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Praveen, Praveen, Wang, Chao, Handley, Thomas N. G., Wu, Hongkang, Samuel, Chrishan S., Bathgate, Ross A. D., Hossain, Mohammed Akhter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094921/ https://www.ncbi.nlm.nih.gov/pubmed/37047588 http://dx.doi.org/10.3390/ijms24076616

Ejemplares similares

Further Developments towards a Minimal Potent Derivative of Human Relaxin-2
por: Handley, Thomas N. G., et al.
Publicado: (2023)

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability
por: Nair, Vinojini B., et al.
Publicado: (2015)

C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity
por: Shabanpoor, Fazel, et al.
Publicado: (2013)

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists
por: Lee, Han Siean, et al.
Publicado: (2020)

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
por: Hossain, Mohammed Akhter, et al.
Publicado: (2016)

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin
por: Bruell, Shoni, et al.
Publicado: (2017)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
por: Kocan, Martina, et al.
Publicado: (2017)

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
por: Praveen, Praveen, et al.
Publicado: (2019)

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design
por: D'Ercole, Annunziata, et al.
Publicado: (2022)

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
por: Bathgate, Ross A. D., et al.
Publicado: (2013)

Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors
por: Tapia Cáceres, Felipe, et al.
Publicado: (2022)

Evolution of the relaxin-like peptide family
por: Wilkinson, Tracey N, et al.
Publicado: (2005)

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
por: Sethi, Ashish, et al.
Publicado: (2016)

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization
por: Chan, Linda J., et al.
Publicado: (2013)

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS
por: Chow, Bryna Suet Man, et al.
Publicado: (2012)

Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds
por: Lee, Han Siean, et al.
Publicado: (2020)

B7‐33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction–Related Adverse Cardiac Remodeling in Mice
por: Devarakonda, Teja, et al.
Publicado: (2020)

Examination of relaxin and its receptors expression in pig gametes and embryos
por: Feugang, Jean M, et al.
Publicado: (2011)

Relaxins enhance growth of spontaneous murine breast cancers as well as metastatic colonization of the brain
por: Binder, Claudia, et al.
Publicado: (2013)

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290
por: Huang, Zaohua, et al.
Publicado: (2015)

Real‐time examination of cAMP activity at relaxin family peptide receptors using a BRET‐based biosensor
por: Valkovic, Adam L., et al.
Publicado: (2018)

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1
por: Pinar, Anita A., et al.
Publicado: (2020)

Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis
por: Hoare, Bradley L., et al.
Publicado: (2019)

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
por: Hoare, Bradley L., et al.
Publicado: (2018)

Relaxin'
Publicado: (1983)

Relaxin
por: DeCherney, Alan H.
Publicado: (1982)

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter
por: Wykes, Alexander D., et al.
Publicado: (2019)

Physical fitness, serum relaxin and duration of gestation
por: Thorell, Eva, et al.
Publicado: (2015)

Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function
por: Callander, Gabrielle E., et al.
Publicado: (2012)

Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data
por: Abboud, Cynthia, et al.
Publicado: (2021)

Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine
por: Koo, Ada, et al.
Publicado: (2022)

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4
por: Lin, Guang-yao, et al.
Publicado: (2020)

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
por: Chen, Yan, et al.
Publicado: (2023)

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate
por: Wang, Chao, et al.
Publicado: (2016)

Trends in serum relaxin concentration among elite collegiate female athletes
por: Dragoo, Jason L, et al.
Publicado: (2011)

The effect of relaxin on the musculoskeletal system
por: Dehghan, F, et al.
Publicado: (2014)

Characterizing relaxin receptor expression and exploring relaxin’s effect on tissue remodeling/fibrosis in the human bladder
por: Diaz, Edward C., et al.
Publicado: (2020)

Relaxin-3-Deficient Mice Showed Slight Alteration in Anxiety-Related Behavior
por: Watanabe, Yoshihisa, et al.
Publicado: (2011)

The Formation and Stabilization of a Novel G-Quadruplex in the 5′-Flanking Region of the Relaxin Gene
por: Lin, Sen, et al.
Publicado: (2012)

Liposomal Entrapment or Chemical Modification of Relaxin2 for Prolongation of Its Stability and Biological Activity
por: Kogkos, George, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_26gsep42301tk57u4lg8kru6vl