Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR

Aberrant aggregation of the transactive response DNA-binding protein (TDP-43) is associated with several lethal neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Cytoplasmic neuronal inclusions of TDP-43 are enriched in various fragments of the low-comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Shenoy, Jayakrishna, Lends, Alons, Berbon, Mélanie, Bilal, Muhammed, El Mammeri, Nadia, Bertoni, Mathilde, Saad, Ahmad, Morvan, Estelle, Grélard, Axelle, Lecomte, Sophie, Theillet, François-Xavier, Buell, Alexander K., Kauffmann, Brice, Habenstein, Birgit, Loquet, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095165/
https://www.ncbi.nlm.nih.gov/pubmed/37065450
http://dx.doi.org/10.3389/fmolb.2023.1148302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095165/
https://www.ncbi.nlm.nih.gov/pubmed/37065450
http://dx.doi.org/10.3389/fmolb.2023.1148302

Ejemplares similares