Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma

Clear cell renal cell carcinoma (ccRCC) is a hypervascular tumor that is characterized by bi-allelic inactivation of the VHL tumor suppressor gene and mTOR signalling pathway hyperactivation. The pro-angiogenic factor PDGFB, a transcriptional target of super enhancer-driven KLF6, can activate the mT...

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Detalles Bibliográficos
Autores principales: Abuhamad, Asmaa Y., Mohamad Zamberi, Nurul Nadia, Vanharanta, Sakari, Mohd Yusuf, Siti Nur Hasanah, Mohtar, M. Aiman, Syafruddin, Saiful Effendi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095210/
https://www.ncbi.nlm.nih.gov/pubmed/37047421
http://dx.doi.org/10.3390/ijms24076447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095210/
https://www.ncbi.nlm.nih.gov/pubmed/37047421
http://dx.doi.org/10.3390/ijms24076447

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