Engineering the Active Site Lid Dynamics to Improve the Catalytic Efficiency of Yeast Cytosine Deaminase

Conformational dynamics is important for enzyme catalysis. However, engineering dynamics to achieve a higher catalytic efficiency is still challenging. In this work, we develop a new strategy to improve the activity of yeast cytosine deaminase (yCD) by engineering its conformational dynamics. Specif...

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Detalles Bibliográficos
Autores principales: Deng, Hanzhong, Qin, Mingming, Liu, Zhijun, Yang, Ying, Wang, Yefei, Yao, Lishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095239/
https://www.ncbi.nlm.nih.gov/pubmed/37047565
http://dx.doi.org/10.3390/ijms24076592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095239/
https://www.ncbi.nlm.nih.gov/pubmed/37047565
http://dx.doi.org/10.3390/ijms24076592

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