Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway

Etoposide (ETO) is an anticancer drug that targets topoisomerase II (TOP2). It stabilizes a normally transient TOP2–DNA covalent complex (TOP2cc), thus leading to DNA double-strand breaks (DSBs). Tyrosyl-DNA phosphodiesterases two (TDP2) is directly involved in the repair of TOP2cc by removing phosp...

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Detalles Bibliográficos
Autores principales: Park, Jeong-Min, Zhang, Huimin, Nie, Litong, Wang, Chao, Huang, Min, Feng, Xu, Tang, Mengfan, Chen, Zhen, Xiong, Yun, Lee, Namsoo, Li, Siting, Yin, Ling, Hart, Traver, Chen, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095316/
https://www.ncbi.nlm.nih.gov/pubmed/37047518
http://dx.doi.org/10.3390/ijms24076545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095316/
https://www.ncbi.nlm.nih.gov/pubmed/37047518
http://dx.doi.org/10.3390/ijms24076545

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