Unraveling Structural Alerts in Marketed Drugs for Improving Adverse Outcome Pathway Framework of Drug-Induced QT Prolongation

In pharmaceutical treatment, many non-cardiac drugs carry the risk of prolonging the QT interval, which can lead to fatal cardiac complications such as torsades de points (TdP). Although the unexpected blockade of ion channels has been widely considered to be one of the main reasons for affecting th...

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Detalles Bibliográficos
Autores principales: Long, Wulin, Li, Shihai, He, Yujie, Lin, Jinzhu, Li, Menglong, Wen, Zhining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095420/
https://www.ncbi.nlm.nih.gov/pubmed/37047744
http://dx.doi.org/10.3390/ijms24076771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095420/
https://www.ncbi.nlm.nih.gov/pubmed/37047744
http://dx.doi.org/10.3390/ijms24076771

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