Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer

Compound 6d, a spiroindoline compound, exhibits antiproliferative capability against cancer cell lines. However, the exact underlying mechanism of this compound-mediated inhibitory capability remains unclear. Here, we showed that compound 6d is an inhibitor of Bcl-2, which suppresses CRC growth by i...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Donglin, He, Liujun, Ma, Shuiqing, Li, Shiqiang, Zhang, Yajun, Hu, Chunsheng, Huang, Jiuhong, Xu, Zhigang, Tang, Dianyong, Chen, Zhongzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095469/
https://www.ncbi.nlm.nih.gov/pubmed/37047634
http://dx.doi.org/10.3390/ijms24076662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095469/
https://www.ncbi.nlm.nih.gov/pubmed/37047634
http://dx.doi.org/10.3390/ijms24076662

Ejemplares similares