Cargando…

Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer

Compound 6d, a spiroindoline compound, exhibits antiproliferative capability against cancer cell lines. However, the exact underlying mechanism of this compound-mediated inhibitory capability remains unclear. Here, we showed that compound 6d is an inhibitor of Bcl-2, which suppresses CRC growth by i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Donglin, He, Liujun, Ma, Shuiqing, Li, Shiqiang, Zhang, Yajun, Hu, Chunsheng, Huang, Jiuhong, Xu, Zhigang, Tang, Dianyong, Chen, Zhongzhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095469/ https://www.ncbi.nlm.nih.gov/pubmed/37047634 http://dx.doi.org/10.3390/ijms24076662

Ejemplares similares

Antiproliferative Evaluation of Novel 4-Imidazolidinone Derivatives as Anticancer Agent Which Triggers ROS-Dependent Apoptosis in Colorectal Cancer Cell
por: Huang, Jiuhong, et al.
Publicado: (2022)

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis
por: Ou, Kepeng, et al.
Publicado: (2022)

Future perspective: high-throughput construction of new ultrasensitive cytokine and virion liquid chips for high-throughput screening (HTS) of anti-inflammatory drugs or clinical diagnosis and treatment of inflammatory diseases
por: Feng, Yingzhu, et al.
Publicado: (2020)

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
por: Gao, Lixia, et al.
Publicado: (2023)

Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage
por: Seng, NS, et al.
Publicado: (2016)

RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1
por: Siddiqui, Mohammad Adnan, et al.
Publicado: (2015)

Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival
por: Lossi, Laura, et al.
Publicado: (2010)

Geometric Signatures as Important Factors to Control the Photo-Stabilities of the Phosphorescent Pd(II)/Pt(II) Complexes: A Case Study
por: Luo, Yafei, et al.
Publicado: (2023)

The road to death: Caspases, cleavage, and pores
por: Dixit, Vishva M.
Publicado: (2023)

Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
por: Yang, Yi, et al.
Publicado: (2017)

CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling
por: Gao, Lixia, et al.
Publicado: (2020)

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage
por: Ko, Hyeonseok, et al.
Publicado: (2015)

A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis
por: Wang, Juanli, et al.
Publicado: (2020)

Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1
por: Lu, Zi-Yi, et al.
Publicado: (2020)

An Efficient Synthesis of Naphtho[2,3-b]furan-4,9-diones via Visible-Light-Mediated [3+2] Cycloaddition Reaction
por: Tan, Hongbo, et al.
Publicado: (2023)

Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio
por: Yi, Jingwen, et al.
Publicado: (2015)

SVM-based prediction of caspase substrate cleavage sites
por: Wee, Lawrence JK, et al.
Publicado: (2006)

Sox11 Reduces Caspase-6 Cleavage and Activity
por: Waldron-Roby, Elaine, et al.
Publicado: (2015)

Caspase-mediated cleavage of the centrosomal proteins during apoptosis
por: Seo, Mi Young, et al.
Publicado: (2018)

Caspase-1 interdomain linker cleavage is required for pyroptosis
por: Ball, Daniel P, et al.
Publicado: (2020)

DDCI-01, a novel long acting phospdiesterase-5 inhibitor, attenuated monocrotaline-induced pulmonary hypertension in rats
por: Li, Ailing, et al.
Publicado: (2020)

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer
por: López-García, Carlos, et al.
Publicado: (2017)

Atorvastatin inhibits cholesterol-induced caspase-3 cleavage through down-regulation of p38 and up-regulation of Bcl-2 in the rat carotid artery
por: Bayatmakoo, Roshanak, et al.
Publicado: (2017)

miR‐140‐3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2
por: Liu, Dingsheng, et al.
Publicado: (2021)

Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells
por: Athamneh, Khawlah, et al.
Publicado: (2020)

Pripper: prediction of caspase cleavage sites from whole proteomes
por: Piippo, Mirva, et al.
Publicado: (2010)

Interactome disassembly during apoptosis occurs independent of caspase cleavage
por: Scott, Nichollas E, et al.
Publicado: (2017)

PAK-2 Targeting to Mitochondria and Cleavage by Caspases Induces Apoptosis
por: Rudel, Thomas, et al.
Publicado: (2001)

Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy
por: Putinski, Charis, et al.
Publicado: (2018)

Caspase Cleavage of Receptor Tyrosine Kinases in the Dependence Receptor Family
por: Park, Gyu Hwan, et al.
Publicado: (2023)

Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades
por: Ding, Jie, et al.
Publicado: (2015)

The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
por: Cui, Jingxia, et al.
Publicado: (2018)

Vascular histone deacetylation by pharmacological HDAC inhibition
por: Rafehi, Haloom, et al.
Publicado: (2014)

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
por: Burgess, Joshua T, et al.
Publicado: (2016)

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
por: Boucher, Dave, et al.
Publicado: (2018)

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
por: Lalaoui, Najoua, et al.
Publicado: (2019)

Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity
por: Wu, Wei, et al.
Publicado: (2021)

Acinus cleavage cuts down on autophagy
por: Short, Ben
Publicado: (2014)

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
por: Wirawan, E, et al.
Publicado: (2010)

Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses
por: Davis, David A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_norhoebgo4l963ah1vo7ej1ica