Impacts of Mutations in the P-Loop on Conformational Alterations of KRAS Investigated with Gaussian Accelerated Molecular Dynamics Simulations

G12 mutations heavily affect conformational transformation and activity of KRAS. In this study, Gaussian accelerated molecular dynamics (GaMD) simulations were performed on the GDP-bound wild-type (WT), G12A, G12D, and G12R KRAS to probe mutation-mediated impacts on conformational alterations of KRA...

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Detalles Bibliográficos
Autores principales: Shi, Shuhua, Zheng, Linqi, Ren, Yonglian, Wang, Ziyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095679/
https://www.ncbi.nlm.nih.gov/pubmed/37049650
http://dx.doi.org/10.3390/molecules28072886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095679/
https://www.ncbi.nlm.nih.gov/pubmed/37049650
http://dx.doi.org/10.3390/molecules28072886

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