Discovery of Novel STING Inhibitors Based on the Structure of the Mouse STING Agonist DMXAA

The stimulator-of-interferon-gene (STING) protein is involved in innate immunity. The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) proved to be a potent murine-STING (mSTING) agonist but had little effect on human-STING (hSTING). In this paper, we draw upon the comparison of different crystal s...

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Detalles Bibliográficos
Autores principales: Chang, Jiajia, Hou, Shi, Yan, Xinlin, Li, Wei, Xiao, Junhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095708/
https://www.ncbi.nlm.nih.gov/pubmed/37049669
http://dx.doi.org/10.3390/molecules28072906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095708/
https://www.ncbi.nlm.nih.gov/pubmed/37049669
http://dx.doi.org/10.3390/molecules28072906

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